Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | VCP | P55072 | 2/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DBH | P09172 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806017 | 0.83 | SDHB (0.46) | ALDH1A1GRK2ROCK2SMN1; SMN2P2RX7 | |
| SCHEMBL30526085 | 0.83 | SDHB (0.46) | ALDH1A1GRK2ROCK2SMN1; SMN2P2RX7 | |
| SCHEMBL23897356 | 0.80 | GRK2 (0.43) | ALDH1A1GRK2ROCK2MAPK1KDM4E | |
| SCHEMBL21020624 | 0.80 | GRK2 (0.43) | ALDH1A1GRK2ROCK2MAPK1SMN1; SMN2 | |
| SCHEMBL19805924 | 0.80 | SMN1; SMN2 (0.37) | ALDH1A1VCPGRK2ROCK2MAPK1 | |
| SCHEMBL19806020 | 0.73 | SDHB (0.60) | MAPK10SMN1; SMN2P2RX7KMT2A | |
| SCHEMBL29976311 | 0.73 | SDHB (0.60) | MAPK10SMN1; SMN2P2RX7KMT2A | |
| SCHEMBL22912258 | 0.71 | MAPT (0.41) | ALDH1A1MAPK10KDM4ESMN1; SMN2MAPT | |
| SCHEMBL20985662 | 0.70 | SDHB (0.42) | ALDH1A1GRK2MAPK10P2RX7MAPT | |
| SCHEMBL19805927 | 0.68 | GRK2 (0.35) | ALDH1A1GRK2ROCK2SMN1; SMN2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |