Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30526075 | 0.86 | GRK2 (0.35) | SMN1; SMN2P2RX7TDP1GRK2DRD4 | |
| SCHEMBL19805927 | 0.86 | GRK2 (0.35) | SMN1; SMN2P2RX7TDP1GRK2DRD4 | |
| SCHEMBL20985705 | 0.85 | SDHB (0.40) | SMN1; SMN2P2RX7GRK2DRD4SIGMAR1 | |
| SCHEMBL22912198 | 0.80 | ALDH1A1 (0.38) | SMN1; SMN2P2RX7TDP1GRK2VCP | |
| SCHEMBL19806106 | 0.80 | VCP (0.32) | VCP | |
| SCHEMBL23897443 | 0.79 | EGFR (0.38) | SMN1; SMN2VCPALDH1A1MEN1KMT2A | |
| SCHEMBL22912304 | 0.79 | HSD17B10 (0.35) | VCPALDH1A1MAPK1 | |
| SCHEMBL22912303 | 0.79 | VCP (0.33) | VCP | |
| SCHEMBL19806024 | 0.78 | EGFR (0.35) | SMN1; SMN2P2RX7VCPALDH1A1MAPK1 | |
| SCHEMBL19805945 | 0.77 | POLB (0.34) | P2RX7VCPALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |