Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22914939 | 0.78 | MAPT (0.48) | MAPTUSP2 | |
| SCHEMBL5128529 | 0.73 | NOTUM (0.54) | RXRAGRIN1GRIN2BNOTUMCYP1A2 | |
| SCHEMBL22914931 | 0.65 | MAPT (0.48) | NOTUMMAPTUSP2 | |
| SCHEMBL29709808 | 0.65 | MAPT (0.48) | NOTUMMAPTUSP2 | |
| SCHEMBL16982958 | 0.65 | NOTUM (0.39) | RXRAGRIN1GRIN2BNOTUMCYP1A2 | |
| SCHEMBL16983100 | 0.64 | RXRA (0.42) | RXRAGRIN1GRIN2BNOTUMCYP3A4 | |
| SCHEMBL5126332 | 0.64 | CYP3A4 (0.39) | RXRAGRIN1GRIN2BNOTUMCYP1A2 | |
| SCHEMBL22914920 | 0.62 | MAPT (0.50) | MAPTUSP2 | |
| SCHEMBL29709838 | 0.62 | MAPT (0.50) | MAPTUSP2 | |
| SCHEMBL5483071 | 0.62 | NR1I2 (0.37) | RXRAGRIN1GRIN2BNOTUMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |