Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | OXTR | P30559 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL502303 | 0.88 | GAA (0.50) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL15926086 | 0.87 | KDM4E (0.49) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL28513088 | 0.83 | GAA (0.41) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL28515919 | 0.83 | GAA (0.41) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL9279836 | 0.83 | GAA (0.63) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL27977498 | 0.83 | KDM4E (0.51) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL9316397 | 0.83 | GAA (0.51) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL14044150 | 0.80 | GAA (0.56) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL6317403 | 0.80 | KDM4E (0.49) | GAAKDM4EMAPTL3MBTL1OXTR | |
| SCHEMBL7999050 | 0.80 | KDM4E (0.49) | GAAKDM4EMAPTL3MBTL1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119747-B1 | METHOD FOR THE PREPARATION OF N- [(6-CHLOROPYRIDIN-3-YL) METHYL] -2,2-DIFLUORETHAN-1-AMINE BY ALKYLATION OF 2,2-DIFLUORETHYLAMINE | BAYER CROPSCIENCE AG (DE) | 2018-08-29 | — | — | EP | claimed |
| US-9890120-B2 | Preparation of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine by alkylation of 2,2-difluoroethylamine | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-02-13 | — | — | US | claimed |
| US-20170081284-A1 | Preparation of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine by alkylation of 2,2-difluoroethylamine | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-03-23 | — | — | US | claimed |
| EP-3119747-A1 | METHOD FOR THE PREPARATION OF N-[(6-CHLOROPYRIDINO-3-YL)METHYL]-2,2-DIFLUOROETHANE-1-AMINE BY THE ALKYLATION OF 2,2-DIFLUOROETHYLAMINE | Bayer CropScience Aktiengesellschaft (DE) | 2017-01-25 | — | — | EP | claimed |
| EP-2867208-B1 | PROCESS FOR PREPARING 2,2-DIFLUOROETHYLAMINE DERIVATIVES BY ALKYLATING 2,2-DIFLUOROETHYLAMINE | BAYER CROPSCIENCE AG (DE) | 2016-08-24 | — | — | EP | claimed |
| US-9376389-B2 | Process for preparing 2,2-difluoroethylamine derivatives by alkylating 2,2-difluoroethylamine | BAYER CROPSCIENCE AG (DE) | 2016-06-28 | — | — | US | claimed |
| US-20150322011-A1 | PROCESS FOR PREPARING 2,2-DIFLUOROETHYLAMINE DERIVATIVES BY ALKYLATING 2,2-DIFLUOROETHYLAMINE | BAYER CROPSCIENCE AG (DE) | 2015-11-12 | — | — | US | claimed |
| WO-2015140198-A1 | METHOD FOR THE PREPARATION OF N-[(6-CHLOROPYRIDINO-3-YL)METHYL]-2,2-DIFLUOROETHANE-1-AMINE BY THE ALKYLATION OF 2,2-DIFLUOROETHYLAMINE | BAYER CROPSCIENCE AG (DE) | 2015-09-24 | — | — | WO | claimed |
| US-8546577-B2 | Substituted enaminocarbonyl compounds | BAYER CROPSCIENCE AG (DE) | 2013-10-01 | — | — | US | claimed |
| US-20130123506-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2013-05-16 | — | — | US | claimed |
| US-8404855-B2 | Substituted enaminocarbonyl compounds | BAYER CROPSCIENCE AG (DE) | 2013-03-26 | — | — | US | claimed |
| US-8344151-B2 | Process for the preparation of 4-aminobut-2-enolides starting from 4-alkoxyfuran-2(5H)-one or 4-arylalkoxyfuran-2(5H)-one | BAYER CROPSCIENCE AG (DE) | 2013-01-01 | — | — | US | claimed |
| US-20120157498-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2012-06-21 | — | — | US | claimed |
| CN-117843559-A | Method for synthesizing chloronicotinyl pesticide intermediate by using multistage series circulation tubular continuous reactor | 沈阳化工研究院有限公司 | 2024-04-09 | — | — | CN | disclosed |
| EP-3119747-B1 | METHOD FOR THE PREPARATION OF N- [(6-CHLOROPYRIDIN-3-YL) METHYL] -2,2-DIFLUORETHAN-1-AMINE BY ALKYLATION OF 2,2-DIFLUORETHYLAMINE | BAYER CROPSCIENCE AG (DE) | 2018-08-29 | — | — | EP | disclosed |
| US-9890120-B2 | Preparation of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine by alkylation of 2,2-difluoroethylamine | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-02-13 | — | — | US | disclosed |
| EP-2004635-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | Bayer CropScience AG (DE) | 2008-12-24 | — | — | EP | disclosed |
| WO-2008009360-A2 | N'-CYANO-N-ALKYL HALIDE IMIDE AMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007115644-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007115644-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG (DE) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157498-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | DDT, NPEPPS, L3MBTL4 | GAA 1096/4885KDM4E 613/4885MAPT 3915/4885 |
| US-20170081284-A1 | Preparation of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine by alkylation of 2,2-difluoroethylamine | DNMT1, AFF1, AFF2 | GAA 924/4885KDM4E 146/4885MAPT 3773/4885 |
| US-20150322011-A1 | PROCESS FOR PREPARING 2,2-DIFLUOROETHYLAMINE DERIVATIVES BY ALKYLATING 2,2-DIFLUOROETHYLAMINE | FANCD2, FANCI, FANCF | GAA 705/4885KDM4E 1215/4885MAPT 4276/4885 |
| US-20130123506-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | DDT, NPEPPS, L3MBTL4 | GAA 1096/4885KDM4E 613/4885MAPT 3915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.