Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28862445 | 0.80 | EIF4E (0.42) | MKNK1EIF4EMKNK2KITBRD4 | |
| SCHEMBL28862512 | 0.74 | KIT (0.48) | MKNK1EIF4EMKNK2LRRK2KIT | |
| SCHEMBL29614332 | 0.70 | MKNK1 (0.47) | MKNK1EIF4EMKNK2LRRK2KIT | |
| SCHEMBL17113554 | 0.65 | LPL (0.47) | MKNK1EIF4EMKNK2LRRK2KIT | |
| SCHEMBL19576506 | 0.64 | ROCK1 (0.46) | MKNK1EIF4EMKNK2BRD4CREBBP | |
| SCHEMBL24958712 | 0.64 | BRD4 (0.45) | MKNK1EIF4EMKNK2KITBRD4 | |
| SCHEMBL25589668 | 0.64 | MKNK1 (0.53) | MKNK1EIF4EMKNK2LRRK2KIT | |
| SCHEMBL25813223 | 0.63 | CXCR3 (0.39) | — | |
| SCHEMBL12690557 | 0.62 | PIM1 (0.39) | MKNK1EIF4EMKNK2LRRK2KIT | |
| SCHEMBL15382060 | 0.62 | PIM1 (0.39) | MKNK1EIF4EMKNK2LRRK2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013864-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL) -PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-01-28 | — | — | WO | disclosed |