Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22919052 | 0.84 | GPR119 (0.50) | USP30GPR119TBK1 | |
| SCHEMBL25193692 | 0.80 | JAK3 (0.43) | USP30GPR119NR1H2NAMPT | |
| SCHEMBL18764769 | 0.79 | L3MBTL1 (0.45) | USP30GPR119NR1H2NAMPT | |
| SCHEMBL3597987 | 0.78 | NR1H2 (0.43) | USP30GPR119NR1H2NAMPT | |
| SCHEMBL15416264 | 0.77 | IRAK1 (0.58) | USP30GPR119IRAK1 | |
| SCHEMBL28956672 | 0.75 | PIK3CD (0.53) | — | |
| SCHEMBL18764929 | 0.75 | GPR119 (0.44) | USP30GPR119NR1H2NAMPT | |
| SCHEMBL15884841 | 0.75 | TBK1 (0.45) | USP30TBK1IRAK1 | |
| SCHEMBL31546905 | 0.75 | NR1H2 (0.40) | USP30GPR119NR1H2NAMPT | |
| SCHEMBL3599876 | 0.72 | NR1H2 (0.38) | USP30GPR119NR1H2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013864-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL) -PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-01-28 | — | — | WO | disclosed |