SCHEMBL2292

SCHEMBL2292

Cc1noc(-c2ccc(-c3ccc(C4(C(=O)O)CC4)cc3)cc2)c1N(C)CCCc1cccc(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.42
LPAR1 Q92633 2/20 0.42
ABCC3 O15438 1/20 0.42
ABCC4 O15439 1/20 0.42
ABCB11 O95342 1/20 0.42
CYP2C8 P10632 1/20 0.42
ABCB4 P21439 1/20 0.42
ABCC2 Q92887 1/20 0.42
SLCO1B3 Q9NPD5 1/20 0.42
SLCO1B1 Q9Y6L6 1/20 0.42
LMNA P02545 1/20 0.37
TSHR P16473 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
SCD5 Q86SK9 1/20 0.36
ALOX5 P09917 1/20 0.34
ALOX5AP P20292 1/20 0.34
AKR1C3 P42330 2/20 0.33
AKR1C2 P52895 2/20 0.33
BRD4 O60885 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2284 0.91 NPSR1 (0.43) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL982 0.90 LPAR1 (0.48) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL1630 0.90 ABCC3 (0.42) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL1403 0.89 LPAR1 (0.41) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL7297 0.88 SCD5 (0.35) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL7466 0.85 LPAR1 (0.47) LPAR1SCD5ALOX5ALOX5APBRD4
SCHEMBL1239 0.84 ABCC3 (0.42) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL2605 0.84 CYP2C9 (0.41) CYP2C9LPAR1ABCC3ABCC4ABCB11
SCHEMBL7572 0.84 SLC26A6 (0.36) LPAR1LMNATSHRNPSR1TDP1
SCHEMBL1127 0.83 LPAR1 (0.43) CYP2C9LPAR1ABCC3ABCC4ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP claimed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO claimed
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed