Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | DNM2 | P50570 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22515648 | 0.91 | TSHR (0.40) | S100A4MCL1L3MBTL1ADAMTS5ALDH1A1 | |
| SCHEMBL25069163 | 0.87 | ADAMTS5 (0.33) | MCL1L3MBTL1ADAMTS5ALDH1A1DNM1 | |
| SCHEMBL24263721 | 0.86 | ADAMTS5 (0.33) | ADAMTS5ALDH1A1DNM1MAPTDNM2 | |
| SCHEMBL18665157 | 0.85 | ALDH1A1 (0.41) | MCL1L3MBTL1ADAMTS5ALDH1A1KDM4E | |
| SCHEMBL24968964 | 0.83 | ALDH1A1 (0.41) | ALDH1A1GPR84DNM2 | |
| SCHEMBL24806215 | 0.82 | GPR84 (0.33) | S100A4MCL1L3MBTL1ADAMTS5ALDH1A1 | |
| SCHEMBL24263719 | 0.81 | ALDH1A1 (0.42) | ADAMTS5ALDH1A1MAPTGPR84DNM2 | |
| SCHEMBL21807012 | 0.80 | MAPT (0.38) | ALDH1A1DNM1MAPTLMNA | |
| SCHEMBL29343844 | 0.80 | CYP3A4 (0.42) | MCL1L3MBTL1ALDH1A1KDM4EDNM1 | |
| SCHEMBL24806133 | 0.79 | MCL1 (0.32) | MCL1L3MBTL1ADAMTS5ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4186518-A1 | POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF | ModernaTX, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
| EP-4011451-A1 | METAPNEUMOVIRUS MRNA VACCINES | ModernaTX, Inc. (US) | 2022-06-15 | — | — | EP | disclosed |
| EP-3458590-B9 | POLYNUCLEOTIDES ENCODING -GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE | MODERNATX INC (US) | 2021-08-18 | — | — | EP | disclosed |
| EP-3458590-B1 | POLYNUCLEOTIDES ENCODING -GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE | MODERNATX INC (US) | 2021-01-27 | — | — | EP | disclosed |