SCHEMBL2292161

SCHEMBL2292161

C#CCOc1c(F)cc(C(=O)NCC2(c3ccccc3)CCCCC2)cc1F

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.57
L3MBTL1 Q9Y468 5/20 0.57
ALDH1A1 P00352 5/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
POLB P06746 1/20 0.52
MAPK1 P28482 1/20 0.52
NPSR1 Q6W5P4 2/20 0.52
GAA P10253 1/20 0.52
MEN1 O00255 7/20 0.47
KMT2A Q03164 7/20 0.47
KDM4E B2RXH2 1/20 0.46
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2287126 0.83 P2RX7 (0.45)
SCHEMBL4249769 0.82 TP53 (0.43) LMNAL3MBTL1
SCHEMBL2289794 0.81 SLC6A5 (0.41) LMNAL3MBTL1
SCHEMBL2289214 0.81 TP53 (0.58) LMNAKDM4E
SCHEMBL2292163 0.80 KCNH2 (0.40) POLB
SCHEMBL2284983 0.80 CNR2 (0.40) L3MBTL1
SCHEMBL2285014 0.78 TP53 (0.43) LMNAL3MBTL1KDM4E
SCHEMBL2289887 0.78 CNR2 (0.38) L3MBTL1
SCHEMBL4244884 0.77 CTSK (0.40)
SCHEMBL2287033 0.77 SLC6A5 (0.36) L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8003699-B2 Amide compound and use thereof for controlling plant diseases SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-08-23 US disclosed
US-20100105647-A1 AMIDE COMPOUND AND USE THEREOF FOR CONTROLLING PLANT DISEASES SUMITOMO CHEMICAL COMPANY, LIMITED 2010-04-29 US disclosed
EP-2151432-A1 AMIDE COMPOUND AND USE THEREOF FOR CONTROLLING PLANT DISEASES Sumitomo Chemical Company, Limited (JP) 2010-02-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100105647-A1 AMIDE COMPOUND AND USE THEREOF FOR CONTROLLING PLANT DISEASES CYC1, CBR3, CBR1 LMNA 3845/4885L3MBTL1 87/4885ALDH1A1 3021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.