Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 17/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.42 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24299824 | 0.93 | KEAP1 (0.45) | KEAP1NFE2L2SQSTM1 | |
| SCHEMBL29539657 | 0.93 | KEAP1 (0.45) | KEAP1NFE2L2SQSTM1 | |
| SCHEMBL26357034 | 0.93 | KEAP1 (0.47) | KEAP1NFE2L2TP53MAPTALDH1A1 | |
| SCHEMBL26357069 | 0.90 | KEAP1 (0.42) | KEAP1NFE2L2TP53MAPTALDH1A1 | |
| SCHEMBL26357214 | 0.89 | NMT1 (0.42) | KEAP1NFE2L2TP53MAPTALDH1A1 | |
| SCHEMBL26356347 | 0.87 | KEAP1 (0.57) | KEAP1NFE2L2SQSTM1TP53MAPT | |
| SCHEMBL26356959 | 0.86 | KEAP1 (0.56) | KEAP1NFE2L2SQSTM1TP53MAPT | |
| SCHEMBL24299972 | 0.86 | KEAP1 (0.39) | KEAP1NFE2L2SQSTM1TP53MAPT | |
| SCHEMBL26357187 | 0.85 | KEAP1 (0.47) | KEAP1NFE2L2SQSTM1MAPTALDH1A1 | |
| SCHEMBL22922454 | 0.85 | KEAP1 (0.48) | KEAP1NFE2L2SQSTM1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2023-10-03 | — | — | US | disclosed |
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2023-10-03 | — | — | US | disclosed |
| WO-2021012721-A1 | NAPHTHALENESULFONAMIDE COMPOUND, PREPARATION METHOD, AND APPLICATION | 中国药科大学 | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773057-B2 | Naphthalenesulfonamide compound, preparation method, and application | NFE2L2, KEAP1, NFE2 | KEAP1 2/4885NFE2L2 1/4885SQSTM1 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.