Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556199 | 0.81 | TOP2A (0.46) | HTR3ATOP2AHTR6KDM4EPOLB | |
| SCHEMBL6562979 | 0.80 | ALDH1A1 (0.62) | HTR3AKDM4EGAARCE1POLB | |
| SCHEMBL11826363 | 0.78 | CYP2D6 (0.59) | TOP2AHTR6KDM4EPOLBALDH1A1 | |
| SCHEMBL11451983 | 0.77 | HTR3A (0.86) | HTR3ATOP2AHTR6KDM4EGAA | |
| SCHEMBL11563042 | 0.77 | HTR3A (0.57) | HTR3ATOP2AHTR6KDM4EPOLB | |
| SCHEMBL11556738 | 0.74 | HTR3A (0.52) | HTR3ATOP2AHTR6KDM4EPOLB | |
| SCHEMBL11561246 | 0.73 | HTR3A (0.51) | HTR3ATOP2AHTR6KDM4EPOLB | |
| SCHEMBL11556407 | 0.73 | HTR3A (0.51) | HTR3ATOP2AHTR6KDM4EPOLB | |
| SCHEMBL822744 | 0.73 | ALDH1A1 (0.59) | ALDH1A1HPGDMEN1KMT2AATM | |
| SCHEMBL10704467 | 0.72 | ALDH1A1 (0.59) | TOP2AHTR6KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-08-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | AZI2, ABL1, RET | HTR3A 538/4885TOP2A 1032/4885HTR6 1206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.