Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.39 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | CLK2 | P49760 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.39 |
| ▸ | CLK3 | P49761 | 2/20 | 0.39 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23497969 | 0.87 | CYP2A6 (0.46) | KDM4EDYRK3CLK1CLK2DYRK1A | |
| SCHEMBL23498018 | 0.81 | HDAC6 (0.36) | KDM4EMAPTALDH1A1MAPKAPK2 | |
| SCHEMBL22130148 | 0.79 | KDM4E (0.59) | KDM4ECHRM1MAPTNSD2ALDH1A1 | |
| SCHEMBL28028402 | 0.79 | BRAF (0.47) | KDM4ECHRM1CLK1CLK2DYRK1A | |
| SCHEMBL27914445 | 0.78 | BACE1 (0.41) | KDM4ECHRM1MAPTNSD2ALDH1A1 | |
| SCHEMBL6618268 | 0.78 | KDM4E (0.43) | KDM4ECHRM1MAPTNSD2ALDH1A1 | |
| Cyanide SCHEMBL22130052 | 0.77 | KDM4E (0.39) | KDM4ECHRM1DYRK3CLK1CLK2 | |
| SCHEMBL21604627 | 0.77 | ALDH1A1 (0.56) | KDM4EDYRK3CLK1CLK2DYRK1A | |
| SCHEMBL29303290 | 0.76 | KDM4E (0.42) | KDM4ECHRM1MAPTNSD2ALDH1A1 | |
| SCHEMBL28499151 | 0.76 | KIF11 (0.39) | KDM4EDYRK1AMAPTALDH1A1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |