Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884574 | 0.85 | CYP2A6 (0.46) | CYP2A6ALDH1A1KDM4EMEN1POLB | |
| SCHEMBL20873801 | 0.78 | PIK3CA (0.44) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL13136913 | 0.77 | HDAC1 (0.51) | CYP2A6ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL13136914 | 0.77 | DYRK1A (0.59) | MAPKAPK2CYP2A6IP6K1BRD4DYRK1A | |
| SCHEMBL22926317 | 0.76 | KDM4E (0.41) | MAPKAPK2ALDH1A1KDM4EMAPTDYRK1A | |
| SCHEMBL29152410 | 0.73 | KIF11 (0.42) | KIF11MAPKAPK2CYP2A6ALDH1A1KDM4E | |
| SCHEMBL17909998 | 0.71 | MAPT (0.41) | ALDH1A1KDM4EMEN1POLBMAPT | |
| SCHEMBL13366943 | 0.71 | KDM4E (0.51) | MAPKAPK2CYP2A6ALDH1A1KDM4EMEN1 | |
| SCHEMBL3360913 | 0.71 | CYP2A6 (0.46) | KIF11CYP2A6ALDH1A1KDM4EMEN1 | |
| SCHEMBL541721 | 0.70 | ALDH1A3 (0.40) | CYP2A6ALDH1A1KDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112521369-A | Compounds and compositions for inhibition of FASN | 福马治疗股份有限公司 | 2021-03-19 | — | — | CN | disclosed |
| CN-105492008-B | Compounds and compositions for inhibition of FASN | 福马治疗股份有限公司 | 2020-11-27 | — | — | CN | disclosed |