Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16099428 | 0.79 | AR (0.62) | HPGDALDH1A1MAPTLMNAAR | |
| SCHEMBL28609425 | 0.78 | RAB9A (0.55) | HPGDALDH1A1MAPTARGAA | |
| SCHEMBL6973873 | 0.76 | ALDH1A1 (0.51) | HPGDALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL19051437 | 0.76 | NPC1 (0.62) | HPGDALDH1A1MAPTARGAA | |
| SCHEMBL18573223 | 0.76 | AR (0.62) | HPGDALDH1A1MAPTLMNAAR | |
| SCHEMBL29044143 | 0.76 | MEN1 (0.66) | HPGDALDH1A1MAPTLMNAGAA | |
| SCHEMBL26613499 | 0.75 | ALDH1A1 (0.60) | HPGDALDH1A1MAPTLMNAAR | |
| SCHEMBL27924669 | 0.75 | ALDH1A1 (0.58) | HPGDALDH1A1MAPTARGAA | |
| SCHEMBL4444933 | 0.75 | HPGD (1.00) | HPGDALDH1A1MAPTLMNAGAA | |
| SCHEMBL28869317 | 0.75 | RAB9A (0.56) | HPGDALDH1A1MAPTARGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |