Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3097068 | 0.84 | ACMSD (0.51) | ALDH1A1MAPTPSEN1PSEN2APH1B | |
| SCHEMBL29384783 | 0.79 | TSHR (0.65) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL322161 | 0.79 | TSHR (0.65) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22926305 | 0.79 | FASN (0.51) | SMN1; SMN2MAOBMAOAALDH1A1MAPT | |
| SCHEMBL3621421 | 0.77 | MAOB (0.47) | TSHRCASP1SMN1; SMN2MAOBMAOA | |
| SCHEMBL8940388 | 0.76 | P2RX1 (0.46) | TSHRCASP1SMN1; SMN2MAOBMAOA | |
| SCHEMBL14294262 | 0.76 | ESR1 (0.50) | KDM4E | |
| SCHEMBL29392929 | 0.76 | MAOB (0.58) | TSHRCASP1SMN1; SMN2MAOBMAOA | |
| SCHEMBL325429 | 0.76 | MAOB (0.58) | TSHRCASP1SMN1; SMN2MAOBMAOA | |
| SCHEMBL14439661 | 0.75 | ALDH1A1 (0.48) | TSHRCASP1SMN1; SMN2MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |