Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23677070 | 0.74 | HDAC6 (0.40) | HTR7KMT2AMEN1 | |
| SCHEMBL21880533 | 0.73 | MAOB (0.43) | KMT2AMAPTMEN1 | |
| SCHEMBL2490498 | 0.71 | HTR7 (0.78) | HTR7HSD17B3KMT2AHPGDNPC1 | |
| SCHEMBL21942480 | 0.70 | MAPT (0.35) | L3MBTL1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL10578417 | 0.69 | HTR7 (0.75) | HTR7HSD17B3KMT2AHPGDNPC1 | |
| SCHEMBL17410393 | 0.69 | FASN (0.38) | KMT2AMEN1 | |
| SCHEMBL17411014 | 0.68 | FASN (0.39) | KMT2ANPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL21880766 | 0.67 | ALDH1A1 (0.44) | KMT2AHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26254861 | 0.66 | HSD17B3 (0.82) | HTR7HSD17B3KMT2AHPGDNPC1 | |
| SCHEMBL25060357 | 0.64 | ALDH1A1 (0.46) | KMT2AHPGDNPC1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |