Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3171683 | 0.79 | VDR (0.52) | CHEK2KDM4EHPGD | |
| SCHEMBL3175974 | 0.75 | CHEK2 (0.52) | CHEK2PTGER4KDM4EHPGD | |
| SCHEMBL6704506 | 0.74 | MAP2K4 (0.54) | CHEK2PTGER4KDM4EHPGD | |
| SCHEMBL18247596 | 0.73 | TDP1 (0.53) | CHEK2KDM4EHPGD | |
| SCHEMBL3175866 | 0.73 | VDR (0.55) | CHEK2 | |
| SCHEMBL121474 | 0.72 | SCN9A (0.68) | KDM4E | |
| SCHEMBL17373146 | 0.71 | POLB (0.50) | KDM4EHPGD | |
| SCHEMBL3162127 | 0.71 | CHEK2 (0.57) | CHEK2PTGER4 | |
| SCHEMBL13350181 | 0.71 | CHEK2 (0.60) | CHEK2PTGER4KDM4EHPGD | |
| SCHEMBL29443096 | 0.71 | CHEK2 (0.60) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257547-B1 | NOVEL BENZIMIDAZOLE LINKED PYRROLOÝ2,1-QÝ1,4¨BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2015-08-05 | — | — | EP | disclosed |
| US-8835421-B2 | Benzimidazole linked pyrrolo[2,1-c[1,4] benzodiazepine hybrids as potential antitumour agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-09-16 | — | — | US | disclosed |
| US-20110190268-A1 | Novel Benzimidazole Linked Pyrrolo[2,1-c[1,4] Benzodiazepine Hybrids as Potential Antitumour Agents and Process for the Preparation Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2011-08-04 | — | — | US | disclosed |
| EP-2257547-A1 | NOVEL BENZIMIDAZOLE LINKED PYRROLOÝ2,1-QÝ1,4¨BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF | Council Of Scientific & Industrial Research (IN) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009113085-A1 | NOVEL BENZIMIDAZOLE LINKED PYRROLO[2,1-Q[1,4] BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190268-A1 | Novel Benzimidazole Linked Pyrrolo[2,1-c[1,4] Benzodiazepine Hybrids as Potential Antitumour Agents and Process for the Preparation Thereof | GABRA1, GABRA4, PBRM1 | PADI4 2563/4885CHEK2 1367/4885PTGER4 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.