Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187984 | 0.82 | KEAP1 (0.49) | AURKATPX2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL29764483 | 0.82 | KEAP1 (0.49) | AURKATPX2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL15826472 | 0.77 | P2RX7 (0.41) | AURKATPX2P2RX7CSNK2A2CSNK2B | |
| SCHEMBL16382729 | 0.76 | NR4A2 (0.50) | KMT2A | |
| SCHEMBL22927040 | 0.76 | FSCN1 (0.36) | AURKAJAK2JAK1BTKKMT2A | |
| SCHEMBL24991888 | 0.74 | P2RX7 (0.46) | P2RX7JAK2JAK1TYK2BTK | |
| SCHEMBL21481904 | 0.74 | P2RX7 (0.46) | P2RX7JAK2JAK1TYK2BTK | |
| SCHEMBL29764491 | 0.74 | JAK2 (0.40) | AURKATPX2P2RX7CSNK2A2CSNK2B | |
| SCHEMBL22531302 | 0.74 | JAK2 (0.40) | AURKATPX2P2RX7CSNK2A2CSNK2B | |
| Acetic Acid SCHEMBL27953393 | 0.73 | CREBBP (0.41) | AURKATPX2P2RX7CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210024491-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | TEMPEST THERAPEUTICS, INC. | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024491-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | PTGER4, PTGER2, CNR2 | AURKA 4109/4885TPX2 1887/4885P2RX7 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.