Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443482 | 0.84 | TSHR (0.58) | TSHRRAB9AMAPTCYP1A2CYP2C19 | |
| SCHEMBL1017792 | 0.83 | KDM4E (0.54) | TSHRRAB9AMAPTKMT2ACYP1A2 | |
| SCHEMBL27904103 | 0.83 | SRD5A2 (0.64) | RAB9AMAPTKMT2AMAPK13MAPK12 | |
| SCHEMBL69263 | 0.83 | KDM4E (0.62) | RAB9AMAPTKMT2ACYP1A2CYP2C19 | |
| SCHEMBL28714550 | 0.82 | KDM4E (0.68) | TSHRRAB9AMAPTKMT2AMAPK13 | |
| SCHEMBL6238741 | 0.80 | ALDH1A1 (0.54) | TSHRRAB9AMAPTKMT2ACYP1A2 | |
| SCHEMBL2496347 | 0.80 | ALDH1A1 (0.57) | TSHRRAB9AMAPTKMT2ACYP1A2 | |
| SCHEMBL28719962 | 0.80 | KDM4E (0.66) | TSHRRAB9AMAPTKMT2AMAPK13 | |
| SCHEMBL28464953 | 0.80 | MAPT (0.52) | RAB9AMAPTKMT2ASRD5A2CYP1A2 | |
| SCHEMBL27983727 | 0.79 | HTT (0.69) | TSHRRAB9AMAPTKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS INC (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4003985-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174290-A | Modulators of TREX1 | 星座制药公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | TSHR 1272/4885RAB9A 1079/4885MAPT 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.