SCHEMBL69263

SCHEMBL69263

COC(=O)c1ccc(C(=O)OC)c(Cl)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.62
ALDH1A1 P00352 7/20 0.62
HPGD P15428 4/20 0.62
MAPT P10636 4/20 0.62
HSD17B10 Q99714 3/20 0.62
ATM Q13315 3/20 0.62
GLA P06280 2/20 0.62
GAA P10253 2/20 0.62
CASP1 P29466 1/20 0.62
CASP7 P55210 1/20 0.62
SMN1; SMN2 Q16637 2/20 0.54
CA12 O43570 2/20 0.53
CA1 P00915 2/20 0.53
CA2 P00918 2/20 0.53
CA7 P43166 2/20 0.53
CA9 Q16790 2/20 0.53
CA14 Q9ULX7 2/20 0.53
XDH P47989 1/20 0.53
ABL1 P00519 1/20 0.51
FLT1 P17948 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2890548 0.91 KDM4E (0.51) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL1017792 0.89 KDM4E (0.54) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL16957205 0.89 KDM4E (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL3116280 0.89 MAPT (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL2496347 0.89 ALDH1A1 (0.57) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL6243384 0.89 KDM4E (0.50) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL1483403 0.89 TSHR (0.55) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL29606273 0.89 TSHR (0.55) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL6238741 0.89 ALDH1A1 (0.54) KDM4EALDH1A1HPGDMAPTHSD17B10
SCHEMBL5058881 0.87 HPGD (0.53) KDM4EALDH1A1HPGDMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4651988-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS ExxonMobil Technology and Engineering Company (US) 2025-11-26 EP claimed
US-20240300983-A1 Method of Making Metal-Organic Frameworks With a Precursor and Crystallization Aid EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) 2024-09-12 US claimed
US-20240254148-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) 2024-08-01 US claimed
WO-2024155562-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS ExxonMobil Technology and Engineering Company (US) 2024-07-25 WO claimed
EP-4363100-A1 METHOD OF MAKING METAL-ORGANIC FRAMEWORKS WITH A PRECURSOR AND CRYSTALLIZATION AID ExxonMobil Technology and Engineering Company (US) 2024-05-08 EP claimed
WO-2023278248-A1 METHOD OF MAKING METAL-ORGANIC FRAMEWORKS WITH A PRECURSOR AND CRYSTALLIZATION AID ExxonMobil Technology and Engineering Company (US) 2023-01-05 WO claimed
EP-4651988-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS ExxonMobil Technology and Engineering Company (US) 2025-11-26 EP disclosed
EP-3233842-B1 BICYCLOHETEROARYL-HETEROARYL-BENZOIC ACID COMPOUNDS AS RETINOIC ACID RECEPTOR BETA (RARB) AGONISTS KING S COLLEGE LONDON (GB) 2025-03-26 EP disclosed
US-20240300983-A1 Method of Making Metal-Organic Frameworks With a Precursor and Crystallization Aid EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) 2024-09-12 US disclosed
US-20240254148-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) 2024-08-01 US disclosed
WO-2024155562-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS ExxonMobil Technology and Engineering Company (US) 2024-07-25 WO disclosed
EP-4363100-A1 METHOD OF MAKING METAL-ORGANIC FRAMEWORKS WITH A PRECURSOR AND CRYSTALLIZATION AID ExxonMobil Technology and Engineering Company (US) 2024-05-08 EP disclosed
US-20240116872-A1 PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING GENENTECH, INC. (US) 2024-04-11 US disclosed
EP-0314126-A2 Process and intermediates for the preparation of halogenated protease inhibitors G.D. Searle & Co. (US) 1989-05-03 EP disclosed
US-4803294-A Process and intermediates for the preparation of halogenated protease inhibitors G. D. SEARLE & CO. (US) 1989-02-07 US disclosed
EP-0238145-A1 Synergistic herbicidal compositions and methods of use. STAUFFER CHEMICAL COMPANY (US) 1987-09-23 EP disclosed
US-4617582-A Heat-sensitive recording sheet MITSUBISHI PAPER MILLS, LTD. (JP) 1986-10-14 US disclosed
US-4587537-A WAX, A TEREPHTHALATE, BENZYL P-HYDROXYBENZOATE DEVELOPER MITSUBISHI PAPER MILLS, LTD. (JP) 1986-05-06 US disclosed
US-4544936-A GLUOTSN VOLOT GOTMRTD; HIGH WHITENESS, LESS FOGGING AND FADING FUJI XEROX CO., LTD. (JP) 1985-10-01 US disclosed
US-4065431-A Thermally stable, rigid polyesters from aromatic dibasic acids and thermally stable, rigid diols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116872-A1 PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING SHH, GLI1, SMO KDM4E 382/4885ALDH1A1 2371/4885HPGD 2664/4885
US-20240254148-A1 METHODS OF MAKING METAL-ORGANIC FRAMEWORKS WITH PRE-LIGANDS HCAR3, POF1B, HCAR1 KDM4E 3465/4885ALDH1A1 363/4885HPGD 160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.