Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22927688 | 0.90 | CYP19A1 (0.42) | NR3C1ALDH1A1NPSR1TSHRMAPT | |
| SCHEMBL22927731 | 0.90 | MAPK1 (0.43) | ALDH1A1NPSR1TSHRMAPTTP53 | |
| SCHEMBL22927861 | 0.85 | KMT2A (0.40) | ALDH1A1NPSR1TSHRMAPTTP53 | |
| SCHEMBL22927676 | 0.83 | MAOB (0.51) | ALDH1A1NPSR1TSHRMAPTTP53 | |
| SCHEMBL29434810 | 0.80 | LMNA (0.43) | ALDH1A1NPSR1TSHRMAPTTP53 | |
| SCHEMBL22927677 | 0.80 | F10 (0.37) | ALDH1A1NPSR1TSHRKMT2AMAPK1 | |
| SCHEMBL22927717 | 0.80 | CASR (0.42) | ALDH1A1TSHRKMT2AGAAMAPK1 | |
| SCHEMBL22927759 | 0.79 | KMT2A (0.43) | ALDH1A1MAPTTP53KMT2ASMN1; SMN2 | |
| SCHEMBL22927803 | 0.78 | HDAC6 (0.38) | ALDH1A1NPSR1TSHRMAPTLMNA | |
| SCHEMBL22927760 | 0.78 | KCNH2 (0.39) | NPSR1LMNAKMT2AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS INC (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4003985-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174290-A | Modulators of TREX1 | 星座制药公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289728-A1 | MODULATORS OF TREX1 | CFTR, SLC10A1, CYP27A1 | NR3C1 225/4885ALDH1A1 693/4885NPSR1 2924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.