Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 1/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29434795 | 1.00 | RORB (0.52) | RORBKCNA5KCNN4NFE2L2TRIM24 | |
| SCHEMBL1860954 | 0.87 | TRIM24 (0.46) | RORBKCNA5KCNN4NFE2L2TRIM24 | |
| SCHEMBL29000590 | 0.84 | RORB (0.49) | RORBKCNA5KCNN4NFE2L2TGFBR1 | |
| SCHEMBL19154063 | 0.81 | TRIM24 (0.47) | NFE2L2TRIM24TRIM33TDO2IDO1 | |
| SCHEMBL4650076 | 0.79 | TRIM24 (0.52) | TRIM24TRIM33IDO1 | |
| Hydrazine SCHEMBL29217437 | 0.79 | TRIM24 (0.44) | NFE2L2TRIM24TRIM33TDO2IDO1 | |
| SCHEMBL13556434 | 0.78 | KCNA5 (0.39) | KCNA5NFE2L2TRIM24TRIM33TGFBR1 | |
| SCHEMBL29796567 | 0.78 | RORB (0.63) | RORBKCNA5KCNN4TGFBR1TGFBR2 | |
| SCHEMBL13388270 | 0.77 | KCNA5 (0.48) | KCNA5TRIM24TRIM33TDO2 | |
| SCHEMBL4051215 | 0.77 | DYRK1A (0.55) | KCNA5NFE2L2PDE4APDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |