SCHEMBL4650076

SCHEMBL4650076

O=Cc1cccnc1-c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 2/20 0.52
TRIM33 Q9UPN9 2/20 0.52
KMT2A Q03164 4/20 0.46
MEN1 O00255 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
LMNA P02545 1/20 0.46
THRB P10828 1/20 0.46
BLM P54132 1/20 0.46
PTGS2 P35354 2/20 0.46
PTGS1 P23219 1/20 0.42
ALDH1A1 P00352 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 2/20 0.40
NPC1 O15118 1/20 0.40
HSP90AA1 P07900 1/20 0.40
IDO1 P14902 1/20 0.40
RAB9A P51151 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HTT P42858 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14841031 0.86 TRIM24 (0.50) TRIM24TRIM33KMT2AMEN1TDP1
SCHEMBL29773795 0.85 TRIM24 (0.61) TRIM24TRIM33KMT2AMEN1TDP1
SCHEMBL29285316 0.85 TRIM24 (0.48) TRIM24TRIM33KMT2AMEN1TDP1
Water SCHEMBL20534686 0.85 TRIM24 (0.48) TRIM24TRIM33KMT2AMEN1TDP1
SCHEMBL19154063 0.83 TRIM24 (0.47) TRIM24TRIM33KMT2ATDP1LMNA
SCHEMBL3719104 0.83 POLB (0.48) TRIM24TRIM33KMT2AALDH1A1
SCHEMBL11437932 0.83 TRIM24 (0.56) TRIM24TRIM33KMT2AMEN1TDP1
SCHEMBL30479918 0.83 TRIM24 (0.47) TRIM24TRIM33KMT2AMEN1TDP1
SCHEMBL15330922 0.83 ERN1 (0.47) TRIM24TRIM33TDP1ALDH1A1SMN1; SMN2
SCHEMBL2635636 0.82 PTGS2 (0.49) TRIM24TRIM33KMT2AMEN1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030176709-A1 Vinyl-phenyl pyridine monomers and polymers prepared thereform KWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY 2003-09-18 US claimed
US-6545159-B2 Suzuki coupling reaction of vinyl-phenylboronic acid and 2-bromopyridine in presence of alkali metallic base and tetrakis/triphenylphosphine/palladium to form styrenepyridine monomer KWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-04-08 US claimed
US-20020198346-A1 Vinyl-phenyl pyridine monomers and polymers prepared thereform KWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY 2002-12-26 US claimed
US-20260070901-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CAMBRIDGE ENTPR LTD (GB) 2026-03-12 US disclosed
EP-2906558-B1 SODIUM CHANNEL BLOCKERS, PREPARATION METHOD THEREOF AND USE THEREOF DAE WOONG PHARMA (KR) 2020-09-02 EP disclosed
EP-3444249-B1 SODIUM CHANNEL BLOCKERS, PREPARATION METHOD THEREOF AND USE THEREOF DAE WOONG PHARMA (KR) 2020-05-13 EP disclosed
EP-3444249-A1 SODIUM CHANNEL BLOCKERS, PREPARATION METHOD THEREOF AND USE THEREOF Daewoong Pharmaceutical Co., Ltd. (KR) 2019-02-20 EP disclosed
US-9376429-B2 Sodium channel blockers, preparation method thereof and use thereof DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2016-06-28 US disclosed
US-20150336944-A1 Sodium Channel Blockers, Preparation Method Thereof and Use Thereof IN THERAPEUTICS (KR) 2015-11-26 US disclosed
US-20150266864-A1 HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN CRISTÁLIA PRODUTOS QUÍMICOS FARMACÊUTICOS LTDA (BR) 2015-09-24 US disclosed
EP-2906558-A1 SODIUM CHANNEL BLOCKERS, PREPARATION METHOD THEREOF AND USE THEREOF Daewoong Pharmaceutical Co., Ltd. (KR) 2015-08-19 EP disclosed
US-20030176709-A1 Vinyl-phenyl pyridine monomers and polymers prepared thereform KWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY 2003-09-18 US disclosed
US-6545159-B2 Suzuki coupling reaction of vinyl-phenylboronic acid and 2-bromopyridine in presence of alkali metallic base and tetrakis/triphenylphosphine/palladium to form styrenepyridine monomer KWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-04-08 US disclosed
US-20020198346-A1 Vinyl-phenyl pyridine monomers and polymers prepared thereform KWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY 2002-12-26 US disclosed
EP-1109804-A1 CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR Millennium Pharmaceuticals, Inc. (US) 2001-06-27 EP disclosed
WO-2000014086-A1 CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR MILLENIUM PHARMACEUTICALS, INC. (US) 2000-03-16 WO disclosed
EP-0148826-A1 FUNGICIDAL, HERBICIDAL AND PLANT GROWTH REGULATING PYRIDYL-CONTAINING ETHERS CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) 1985-07-24 EP disclosed
WO-1985000289-A1 FUNGICIDAL, HERBICIDAL AND PLANT GROWTH REGULATING PYRIDYL-CONTAINING ETHERS CHEVRON RESEARCH COMPANY (US) 1985-01-31 WO disclosed
US-4407806-A PRE- AND POSTEMERGENCE HERBICIDES CHEVRON RESEARCH COMPANY (US) 1983-10-04 US disclosed
US-4376769-A Substituted imidazo thiazoles thiazines, thiazepines and thiazocines SCHERING CORPORATION (US) 1983-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150266864-A1 HETEROAROMATIC COMPOUNDS, METHOD FOR PREPARING THE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND METHOD FOR TREATING ACUTE AND CHRONIC PAIN TRPV1, AP1G1, INA TRIM24 3740/4885TRIM33 4080/4885KMT2A 2470/4885
US-20150336944-A1 Sodium Channel Blockers, Preparation Method Thereof and Use Thereof SCN7A, SCN1A, SCN5A TRIM24 4199/4885TRIM33 4622/4885KMT2A 2688/4885
US-20260070901-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CSNK1A1, CSNK2A3, CSNK1G1 TRIM24 1597/4885TRIM33 3449/4885KMT2A 250/4885
US-20020198346-A1 Vinyl-phenyl pyridine monomers and polymers prepared thereform VAT1, PBRM1, THEM6 TRIM24 1028/4885TRIM33 1487/4885KMT2A 1924/4885
US-20030176709-A1 Vinyl-phenyl pyridine monomers and polymers prepared thereform VAT1, PBRM1, THEM6 TRIM24 1028/4885TRIM33 1487/4885KMT2A 1924/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.