Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22928607 | 0.79 | MEN1 (0.37) | ALOX15LMNASMN1; SMN2MEN1POLB | |
| SCHEMBL22928584 | 0.78 | FPR2 (0.37) | MAOALMNASMN1; SMN2MEN1POLB | |
| SCHEMBL4989751 | 0.74 | CA1 (0.35) | ALOX15LMNASMN1; SMN2MEN1POLB | |
| SCHEMBL23893797 | 0.72 | KIF11 (0.33) | MAOAMEN1KMT2AKIF11TSHR | |
| SCHEMBL7944567 | 0.70 | CYP2A6 (0.40) | ALOX15MEN1POLBKMT2ACA1 | |
| SCHEMBL8582556 | 0.69 | MEN1 (0.56) | ALOX15LMNAMEN1POLBKMT2A | |
| SCHEMBL18911463 | 0.69 | CYP2A6 (0.44) | ALOX15LMNAMEN1POLBKMT2A | |
| SCHEMBL155856 | 0.69 | CYP2A6 (0.44) | ALOX15LMNAMEN1POLBKMT2A | |
| SCHEMBL18911320 | 0.69 | FPR2 (0.36) | LMNASMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL19448778 | 0.69 | CYP3A4 (0.39) | ALOX15LMNASMN1; SMN2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3380101-B1 | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO | EFFECTOR THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |