Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.63 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.63 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.63 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.63 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.63 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.63 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315940 | 0.91 | GRIN2D (0.56) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5362237 | 0.85 | GRIN2D (0.67) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL9621424 | 0.85 | SLC6A4 (0.68) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL7498044 | 0.82 | MEN1 (0.50) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5362231 | 0.82 | GRIN2D (0.57) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL6174349 | 0.82 | SLC6A4 (0.60) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5967992 | 0.80 | TSHR (0.59) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL8259606 | 0.79 | GRIN2D (0.56) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL20854546 | 0.78 | DRD4 (0.73) | DRD2DRD4DRD3 | |
| SCHEMBL12473966 | 0.78 | RAD52 (0.56) | GRIN2DGRIN3BADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11365195-B2 | Atypical inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-06-21 | — | — | US | disclosed |
| US-20210024523-A1 | ATYPICAL INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024523-A1 | ATYPICAL INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | SLC18A2, SLC6A3, SLC6A4 | GRIN2D 102/4885GRIN3B 222/4885ADRA1D 59/4885 |
| US-11365195-B2 | Atypical inhibitors of monoamine transporters; method of making; and use thereof | SLC18A2, SLC6A3, SLC6A4 | GRIN2D 102/4885GRIN3B 222/4885ADRA1D 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.