Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.56 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315940 | 0.82 | GRIN2D (0.56) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL27701808 | 0.81 | GRIN2D (0.58) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL9621424 | 0.79 | SLC6A4 (0.68) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL22928809 | 0.79 | GRIN2D (0.63) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5074371 | 0.77 | GRIN2D (0.51) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5362237 | 0.77 | GRIN2D (0.67) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL359069 | 0.76 | ACHE (0.79) | ACHECYP2D6 | |
| SCHEMBL358435 | 0.76 | ACHE (0.79) | ACHECYP2D6 | |
| SCHEMBL1286699 | 0.76 | ACHE (0.79) | ACHECYP2D6 | |
| SCHEMBL6174349 | 0.76 | SLC6A4 (0.60) | GRIN2DGRIN3BADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006113471-A2 | N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2006-10-26 | — | — | WO | disclosed |