Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.67 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.67 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.67 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.57 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.56 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.54 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22928809 | 0.85 | GRIN2D (0.63) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL9621424 | 0.82 | SLC6A4 (0.68) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5362231 | 0.80 | GRIN2D (0.57) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL6986594 | 0.79 | CARM1 (0.69) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL4315940 | 0.79 | GRIN2D (0.56) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL6174349 | 0.79 | SLC6A4 (0.60) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7035790 | 0.78 | CARM1 (0.67) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL27701808 | 0.78 | GRIN2D (0.58) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL5967992 | 0.78 | TSHR (0.59) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL8259606 | 0.77 | GRIN2D (0.56) | GRIN2DGRIN3BADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892584-B | Fluorescent probe and preparation method and application thereof | 国家纳米科学中心 | 2022-01-11 | — | — | CN | claimed |
| CN-111808017-B | Nitrogen-containing heterocyclic compound, and preparation method and application thereof | 国家纳米科学中心 | 2023-11-28 | — | — | CN | disclosed |
| CN-111892584-B | Fluorescent probe and preparation method and application thereof | 国家纳米科学中心 | 2022-01-11 | — | — | CN | disclosed |
| CN-111892584-A | Fluorescent probe and preparation method and application thereof | 国家纳米科学中心 | 2020-11-06 | — | — | CN | disclosed |
| CN-111808017-A | Nitrogen-containing heterocyclic compound and preparation method and application thereof | 国家纳米科学中心 | 2020-10-23 | — | — | CN | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-20040204341-A1 | Nr2b receptor antagonists for the treatment or prevention of migraines | ALLEN CHRISTOPHER (US) | 2004-10-14 | — | — | US | disclosed |
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK SHARP & DOHME CORP. | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204341-A1 | Nr2b receptor antagonists for the treatment or prevention of migraines | HTR1B, HTR2B, HTR1A | GRIN2D 26/4885GRIN3B 13/4885ADRA1D 286/4885 |
| US-20030119811-A1 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | GRIN1, GRIN2B, GRIN2A | GRIN2D 7/4885GRIN3B 6/4885ADRA1D 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.