Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293851 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTNAMPTALOX15MEN1 | |
| SCHEMBL5262578 | 0.84 | CYP2C9 (0.47) | SMN1; SMN2MAPTMEN1KMT2ACYP2C9 | |
| SCHEMBL3289861 | 0.84 | CYP2C9 (0.47) | SMN1; SMN2MAPTMEN1KMT2ACYP2C9 | |
| SCHEMBL12420159 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C9HRH3 | |
| SCHEMBL5163118 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C9HRH3 | |
| SCHEMBL4799395 | 0.82 | CYP2C9 (0.53) | MAPTALOX15POLBCYP2C9HRH3 | |
| SCHEMBL4799387 | 0.82 | CYP2C9 (0.53) | MAPTALOX15POLBCYP2C9HRH3 | |
| SCHEMBL4003420 | 0.82 | CA12 (0.59) | SMN1; SMN2MAPTMEN1KMT2ACYP2C9 | |
| SCHEMBL3962996 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTNAMPTALOX15MEN1 | |
| SCHEMBL5265413 | 0.81 | KDM1A (0.55) | SMN1; SMN2MEN1KMT2ACYP2C9HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190529-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)-AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | SANOFI-AVENTIS (FR) | 2011-08-04 | — | — | US | disclosed |
| US-20110190529-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)-AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | SANOFI-AVENTIS (FR) | 2011-08-04 | — | — | US | disclosed |
| US-20110190529-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)-AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | SANOFI-AVENTIS (FR) | 2011-08-04 | — | — | US | disclosed |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| WO-2010020719-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | SANOFIS-AVENTIS (FR) | 2010-02-25 | — | — | WO | disclosed |
| US-7625929-B2 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7453010-B2 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2006-05-11 | — | — | US | disclosed |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | SANOFI-AVENTIS (FR) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | CHRM1, CHRM2, C1R | SMN1; SMN2 2695/4885MAPT 3646/4885NAMPT 2632/4885 |
| US-20110190529-A1 | METHOD FOR PREPARING THE ETHYL ESTER OF 4-[TRANS-4-[(PHENYLMETHYL)-AMINO]CYCLOHEXYL]BENZOIC ACID AND THE HEMIFUMARATE SALT THEREOF | CYP4F11, CYP51A1, CYP4F2 | SMN1; SMN2 3167/4885MAPT 2085/4885NAMPT 900/4885 |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | HRH4, HRH3, AOC3 | SMN1; SMN2 1882/4885MAPT 3137/4885NAMPT 3011/4885 |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | HRH4, HRH3, HTR3C | SMN1; SMN2 1850/4885MAPT 2619/4885NAMPT 2957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.