Isatin

Isatin

SCHEMBL2293849

CC(=O)C(C(=O)O)[C@H](N)C(=O)O.O=C1N=c2ccccc2=C1O

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.36
MEN1 O00255 2/20 0.36
POLB P06746 2/20 0.36
SLC1A2 P43004 2/20 0.35
ATM Q13315 1/20 0.34
MAPT P10636 5/20 0.33
ALDH1A1 P00352 2/20 0.33
LMNA P02545 2/20 0.33
MAPK10 P53779 2/20 0.33
PKM P14618 2/20 0.33
ALOX15 P16050 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CCR6 P51684 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
KDR P35968 1/20 0.33
TGM2 P21980 1/20 0.33
SLC1A3 P43003 2/20 0.31
ALPI P09923 2/20 0.31
NLRP3 Q96P20 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isatin SCHEMBL7073534 0.76 MAPT (0.47) KMT2AMEN1POLBATMMAPT
SCHEMBL1460670 0.75 SLC1A2 (0.33) KMT2AMEN1SLC1A2MAPTPKM
Isatin SCHEMBL30956357 0.74 MAPT (0.46) KMT2AMEN1POLBATMMAPT
Isatin SCHEMBL28827543 0.70 MAPT (0.43) KMT2AMEN1POLBATMMAPT
SCHEMBL29524472 0.69 SLC7A5 (0.57) SLC1A2MAPTALDH1A1SLC1A3SLC1A1
SCHEMBL5284864 0.69 SLC7A5 (0.57) SLC1A2MAPTALDH1A1SLC1A3SLC1A1
Alanine SCHEMBL11605093 0.67 ELANE (0.40) POLBSLC1A2LMNAPKMALPI
SCHEMBL27500106 0.64 ATM (0.38) KMT2AMEN1POLBATMMAPT
SCHEMBL28737069 0.64 ATM (0.40) KMT2AMEN1POLBATMMAPT
Indole SCHEMBL3738189 0.63 TRPA1 (0.49) KMT2AMEN1SLC1A2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150038544-A1 ANIMAL FEED COMPOSITION VEIJLEN N.V. (AN) 2015-02-05 US disclosed
US-8883233-B2 Animal feed composition VEIJLEN N.V. (AN) 2014-11-11 US disclosed
US-20120283308-A1 ANIMAL FEED COMPOSITION VEIJLEN N. V. (AN) 2012-11-08 US disclosed
US-20110196013-A1 Animal feed composition VEIJLEN N.V. (AN) 2011-08-11 US disclosed
US-20070184091-A1 Animal feed composition VEIJLEN N.V. (AN) 2007-08-09 US disclosed
EP-1667678-A1 ANIMAL FEED COMPOSITION Veijlen N.V. (AN) 2006-06-14 EP disclosed
WO-2005034942-A1 ANIMAL FEED COMPOSITION VEIJLEN N.V. (AN) 2005-04-21 WO disclosed