Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20570318 | 0.83 | PNMT (0.42) | PNMTTAAR1TDP1SIGMAR1IGF1R | |
| SCHEMBL177296 | 0.82 | PNMT (0.61) | PNMTTAAR1SIGMAR1IGF1RALOX15 | |
| SCHEMBL507688 | 0.82 | CYP4F2 (0.40) | PNMTTAAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL30019331 | 0.82 | PNMT (0.61) | PNMTTAAR1SIGMAR1IGF1RALOX15 | |
| SCHEMBL29434697 | 0.81 | ALDH1A1 (0.47) | PNMTTAAR1TDP1SIGMAR1IGF1R | |
| SCHEMBL17186197 | 0.81 | TAAR1 (0.67) | PNMTTAAR1TDP1SIGMAR1ALOX15 | |
| SCHEMBL11974004 | 0.81 | CNR1 (0.44) | PNMTTAAR1SIGMAR1MEN1ALDH1A1 | |
| SCHEMBL2299809 | 0.81 | ALDH1A1 (0.47) | PNMTTAAR1TDP1SIGMAR1IGF1R | |
| SCHEMBL7657078 | 0.79 | TDP1 (0.44) | TAAR1TDP1IGF1RALOX15MEN1 | |
| SCHEMBL27908984 | 0.79 | PNMT (0.36) | PNMTTAAR1TDP1SIGMAR1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102498103-A | Pyrazine carboxamides as DGAT1 inhibitors | ASTRAZENECA AB | 2012-06-13 | — | — | CN | disclosed |
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |
| CN-102083783-A | Substituted biphenyl GPR40 modulators | AMGEN INC | 2011-06-01 | — | — | CN | disclosed |