Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177296 | 1.00 | PNMT (0.61) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL79213 | 0.86 | IGF1R (0.58) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL8211623 | 0.83 | IGF1R (0.59) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL7009306 | 0.83 | IGF1R (0.59) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL11389115 | 0.83 | IGF1R (0.59) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL20570318 | 0.82 | PNMT (0.42) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL2294256 | 0.82 | PNMT (0.42) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL10830848 | 0.80 | CYP3A4 (0.43) | PNMTTAAR1SIGMAR1CYP1A2MEN1 | |
| SCHEMBL10977494 | 0.80 | CYP3A4 (0.63) | PNMTTAAR1IDO1SIGMAR1IGF1R | |
| SCHEMBL7458179 | 0.80 | PNMT (0.41) | PNMTTAAR1SIGMAR1IGF1RALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226290-A1 | 2-PHENYLAMINO PYRROLOPYRIMIDINES AS ACK1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-10-27 | — | — | WO | disclosed |