Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147411 | 0.95 | LMNA (0.73) | LMNAALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL28013124 | 0.93 | LMNA (0.70) | LMNAALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL2524087 | 0.88 | LMNA (0.61) | LMNAALDH1A1MMP1MMP2MMP3 | |
| Hexadecanoic Acid Diethylamide SCHEMBL28057571 | 0.87 | LMNA (0.61) | LMNAALDH1A1TSHRSOAT1MEN1 | |
| SCHEMBL3306771 | 0.85 | LMNA (0.89) | LMNAALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL11495132 | 0.82 | FAAH (0.65) | LMNAMMP2SOAT1MEN1FAAH | |
| SCHEMBL11495133 | 0.82 | FAAH (0.65) | LMNAMMP2SOAT1MEN1FAAH | |
| SCHEMBL13630657 | 0.82 | LMNA (0.84) | LMNAALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL3347764 | 0.82 | ALDH1A1 (0.55) | LMNAALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL15378315 | 0.81 | LMNA (0.81) | LMNAALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | disclosed |