SCHEMBL22945668

SCHEMBL22945668

Cc1ccc(S(=O)(=O)OCCCC(C)(F)c2ccccc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 1/20 0.41
PTGS2 P35354 1/20 0.39
CYP3A4 P08684 2/20 0.38
CYP2C19 P33261 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
VDR P11473 1/20 0.37
ALDH1A1 P00352 2/20 0.36
STAT3 P40763 1/20 0.36
GAA P10253 2/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MCHR1 Q99705 1/20 0.36
FFAR1 O14842 1/20 0.36
CDK1 P06493 1/20 0.36
CCNB1 P14635 1/20 0.36
CCNA2 P20248 1/20 0.36
CDK2 P24941 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28719294 0.88 CYP24A1 (0.42) CYP24A1PTGS2CYP3A4CYP2C19MEN1
SCHEMBL15270828 0.83 CA12 (0.40) CYP24A1PTGS2CYP3A4CYP2C19MEN1
SCHEMBL24488898 0.82 CYP24A1 (0.40) CYP24A1PTGS2CYP3A4CYP2C19MEN1
SCHEMBL283084 0.82 ALDH1A1 (0.41) CYP24A1CYP3A4CYP2C19MEN1KMT2A
SCHEMBL13886464 0.82 ALDH1A1 (0.41) CYP24A1PTGS2CYP3A4CYP2C19MEN1
SCHEMBL6005376 0.80 KIF11 (0.47) CYP24A1CYP3A4CYP2C19MEN1KMT2A
SCHEMBL19069752 0.80 ALDH1A1 (0.42) CYP24A1CYP3A4CYP2C19MEN1KMT2A
SCHEMBL2348771 0.79 PSMD10 (0.41) CYP24A1CYP3A4CYP2C19MEN1KMT2A
SCHEMBL955492 0.78 CYP2C19 (0.43) CYP24A1CYP3A4CYP2C19MEN1KMT2A
SCHEMBL31516447 0.78 TK1 (0.46) CYP24A1CYP3A4CYP2C19VDRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4008405-A1 UREA COMPOUND FOR ANTAGONIZING LPA1 RECEPTOR Taisho Pharmaceutical Co., Ltd. (JP) 2022-06-08 EP disclosed
WO-2021020429-A1 UREA COMPOUND FOR ANTAGONIZING LPA1 RECEPTOR 大正製薬株式会社 2021-02-04 WO disclosed