Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22947521 | 0.96 | KDM4E (0.44) | KDM4ETDP1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22949299 | 0.86 | MEN1 (0.39) | KDM4ERAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL22947514 | 0.85 | MEN1 (0.40) | KDM4ERAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL22949539 | 0.83 | KDM4E (0.43) | KDM4ETDP1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22947357 | 0.83 | KDM4E (0.45) | KDM4ETDP1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22949661 | 0.81 | KDM4E (0.43) | KDM4ETDP1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22947695 | 0.81 | MEN1 (0.40) | KDM4ERAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL22947646 | 0.81 | MEN1 (0.40) | KDM4ERAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL22949337 | 0.80 | MEN1 (0.43) | KDM4ETDP1RAB9AHPGDLMNA | |
| SCHEMBL22947655 | 0.79 | L3MBTL1 (0.42) | KDM4ERAB9ASMN1; SMN2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210036245-A1 | HETEROAROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210036245-A1 | HETEROAROMATIC COMPOUNDS | ETV6, FES, LEF1 | KDM4E 3379/4885TDP1 4017/4885RAB9A 2662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.