Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.50 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | ULK1 | O75385 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22951320 | 0.90 | EGFR (0.47) | EGFRBTKJAK2CHEK1AURKA | |
| SCHEMBL25001622 | 0.89 | EGFR (0.48) | EGFRBTK | |
| SCHEMBL22950971 | 0.88 | EGFR (0.57) | EGFRBTKJAK2CHEK1AURKA | |
| SCHEMBL22950997 | 0.88 | EGFR (0.46) | EGFRBTKALKLRRK2 | |
| SCHEMBL29560175 | 0.85 | EGFR (0.55) | EGFRULK1JAK2LRRK2 | |
| SCHEMBL23441671 | 0.82 | EGFR (0.51) | EGFRBTKULK1JAK2ALK | |
| SCHEMBL25001626 | 0.81 | EGFR (0.56) | EGFRBTKULK1JAK2INSR | |
| SCHEMBL23759571 | 0.81 | EGFR (0.52) | EGFRBTKULK1JAK2INSR | |
| SCHEMBL25001890 | 0.81 | EGFR (0.55) | EGFRBTK | |
| SCHEMBL25001621 | 0.80 | EGFR (0.62) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018009-A1 | EGFR INHIBITOR, COMPOSITION, AND PREPARATION METHOD THEREFOR | 贝达药业股份有限公司 | 2021-02-04 | — | — | WO | disclosed |