Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | ULK1 | O75385 | 3/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001623 | 0.89 | EGFR (0.64) | EGFRBTKJAK2MAP4K1 | |
| SCHEMBL25001983 | 0.88 | EGFR (0.57) | EGFRBTKULK1TTKALK | |
| SCHEMBL25001890 | 0.87 | EGFR (0.55) | EGFRBTKTTK | |
| SCHEMBL23441900 | 0.85 | EGFR (0.59) | EGFRBTKULK1TTKALK | |
| SCHEMBL25001789 | 0.83 | EGFR (0.69) | EGFRBTKULK1ALKINSR | |
| SCHEMBL25001951 | 0.82 | EGFR (0.66) | EGFRBTKULK1TTKALK | |
| SCHEMBL25001534 | 0.82 | EGFR (0.56) | EGFR | |
| SCHEMBL25820802 | 0.81 | EGFR (0.58) | EGFRBTKULK1TTK | |
| SCHEMBL22951336 | 0.81 | EGFR (0.50) | EGFRBTKULK1ALKINSR | |
| SCHEMBL25001947 | 0.81 | EGFR (0.54) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |