Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.55 |
| ▸ | ULK1 | O75385 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29559735 | 0.94 | EGFR (0.65) | EGFRJAK2 | |
| SCHEMBL22942330 | 0.87 | EGFR (0.67) | EGFRJAK2 | |
| SCHEMBL22951336 | 0.85 | EGFR (0.50) | EGFRULK1LRRK2JAK2 | |
| SCHEMBL22950972 | 0.84 | ULK1 (0.45) | EGFRULK1LRRK2JAK2 | |
| SCHEMBL22942878 | 0.82 | ALK (0.63) | EGFRLRRK2JAK2 | |
| SCHEMBL29559900 | 0.82 | ALK (0.63) | EGFRLRRK2JAK2 | |
| SCHEMBL22942151 | 0.82 | EGFR (0.77) | EGFRJAK2 | |
| SCHEMBL22804313 | 0.80 | EGFR (0.81) | EGFRJAK2 | |
| SCHEMBL22595549 | 0.80 | EGFR (0.68) | EGFR | |
| SCHEMBL22942226 | 0.80 | EGFR (0.56) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114430740-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-114430740-B | EGFR inhibitors, compositions and methods of making the same | 贝达药业股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-114430740-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | disclosed |