Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 10/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.40 |
| ▸ | KIF20B | Q96Q89 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283183 | 0.81 | PKM (0.50) | PKMGRM2 | |
| SCHEMBL3278014 | 0.77 | MAPK1 (0.37) | PKMGRM2 | |
| SCHEMBL3435023 | 0.74 | PLK1 (0.51) | PKM | |
| SCHEMBL7812114 | 0.70 | PDE2A (0.38) | GABRA2GABRB2GABRB3KIF20BPDE2A | |
| SCHEMBL3285305 | 0.69 | MAPK1 (0.37) | PKM | |
| SCHEMBL29693589 | 0.69 | PKM (0.75) | PKMGRM2PDE2APDE10A | |
| SCHEMBL1812769 | 0.69 | PKM (0.75) | PKMGRM2PDE2APDE10A | |
| SCHEMBL6551713 | 0.68 | PKM (0.57) | PKMGRM2PDE2A | |
| SCHEMBL3283730 | 0.68 | MAPT (0.65) | — | |
| SCHEMBL3325917 | 0.67 | PDE2A (0.42) | GABRA2GABRB2GABRB3PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760701-B2 | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YROK (US) | 2023-09-19 | — | — | US | disclosed |
| US-20210032181-A1 | DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032181-A1 | DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME | AFF2, AFF4, AFF1 | PKM 2785/4885GABRA2 3349/4885GABRB2 3861/4885 |
| US-11760701-B2 | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same | AFF2, AFF4, AFF1 | PKM 2785/4885GABRA2 3349/4885GABRB2 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.