Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.37 |
| ▸ | GABRP | O00591 | 3/20 | 0.35 |
| ▸ | GABRD | O14764 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.35 |
| ▸ | GABRE | P78334 | 3/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KIF20B | Q96Q89 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812344 | 0.82 | GRM2 (0.42) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL7805418 | 0.75 | GABRA2 (0.36) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL7810834 | 0.71 | KIF11 (0.42) | PDE2APDE10A | |
| SCHEMBL22954114 | 0.70 | PKM (0.49) | PDE2APDE10AGABRA2GABRB2GABRB3 | |
| SCHEMBL3651143 | 0.68 | PKM (0.50) | PDE2APDE10A | |
| SCHEMBL7818166 | 0.66 | GRM2 (0.40) | HSD11B1 | |
| SCHEMBL2791778 | 0.65 | PDE2A (0.53) | PDE2APDE10AGABRA2GABRB2GABRB3 | |
| SCHEMBL5982858 | 0.65 | PDE10A (0.31) | PDE2APDE10A | |
| SCHEMBL5006009 | 0.64 | KIF20B (0.35) | PDE2APDE10AGABRA2GABRB2GABRB3 | |
| SCHEMBL6665560 | 0.64 | CBFB (0.42) | GABRA2GABRB2GABRB3GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |