Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627678 | 0.92 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL22627744 | 0.88 | ALDH1A1 (0.41) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22627899 | 0.87 | ALDH1A1 (0.45) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22627651 | 0.86 | KMT2A (0.56) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22956194 | 0.85 | ATF4 (0.41) | ALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL22627794 | 0.85 | LOXL2 (0.43) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22956500 | 0.85 | ALDH1A1 (0.41) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22956458 | 0.85 | ALDH1A1 (0.43) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22628187 | 0.84 | RXFP1 (0.57) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL22956244 | 0.84 | GRM4 (0.48) | ALDH1A1GRIN1GRIN2BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913727-B2 | Modulators of the integrated stress pathway | ABBVIE INC. (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913727-B2 | Modulators of the integrated stress pathway | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885GRIN1 1690/4885GRIN2B 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.