Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATF4 | P18848 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22956176 | 0.93 | ALDH1A1 (0.39) | MEN1KMT2AATF4ALDH1A1RXFP1 | |
| SCHEMBL25797260 | 0.89 | ALDH1A1 (0.41) | MEN1KMT2AATF4ALDH1A1RXFP1 | |
| SCHEMBL22956222 | 0.89 | MEN1 (0.41) | MEN1KMT2AATF4RXFP1 | |
| SCHEMBL22956184 | 0.88 | ALDH1A1 (0.43) | MEN1KMT2AATF4ALDH1A1POLB | |
| SCHEMBL22956383 | 0.86 | HDAC3 (0.40) | MEN1KMT2AATF4ALDH1A1RXFP1 | |
| SCHEMBL22956149 | 0.85 | ATF4 (0.39) | MEN1KMT2AATF4ALDH1A1RXFP1 | |
| SCHEMBL25809989 | 0.85 | MEN1 (0.40) | MEN1KMT2AATF4L3MBTL1ALDH1A1 | |
| SCHEMBL25817460 | 0.85 | ALDH1A1 (0.42) | MEN1KMT2AATF4ALDH1A1RXFP1 | |
| SCHEMBL25819800 | 0.84 | ATF4 (0.45) | ATF4L3MBTL1ALDH1A1 | |
| SCHEMBL22627886 | 0.84 | ATF4 (0.41) | MEN1KMT2AATF4L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913727-B2 | Modulators of the integrated stress pathway | ABBVIE INC. (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913727-B2 | Modulators of the integrated stress pathway | ATF4, ATF1, DDIT3 | MEN1 4714/4885KMT2A 4320/4885ATF4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.