Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957819 | 0.83 | RIPK1 (0.58) | RIPK1SLC6A4SLC6A2HTR2AHRH1 | |
| SCHEMBL14256506 | 0.81 | HTT (0.50) | RIPK1SLC6A4SLC6A2HTR2AHTT | |
| SCHEMBL3134684 | 0.80 | SLC6A4 (0.75) | RIPK1SLC6A4SLC6A2HTR2AHRH1 | |
| SCHEMBL12201562 | 0.80 | ALDH1A1 (0.59) | HTTKDM4EALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL10245660 | 0.79 | HTT (0.57) | HTTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL1192098 | 0.78 | RIPK1 (0.49) | RIPK1SLC6A4SLC6A2HTR2AHRH1 | |
| SCHEMBL22957896 | 0.78 | HRH1 (0.56) | RIPK1SLC6A4SLC6A2HTR2AHRH1 | |
| SCHEMBL22957634 | 0.78 | HTT (0.47) | RIPK1SLC6A4HTR2AHTTKDM4E | |
| SCHEMBL14256508 | 0.78 | GAA (0.58) | RIPK1SLC6A4HTR2AALDH1A1KMT2A | |
| SCHEMBL6256507 | 0.77 | GAA (0.59) | RIPK1SLC6A4SLC6A2HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913738-B2 | Aminotriazolopyridines as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913738-B2 | Aminotriazolopyridines as kinase inhibitors | RIPK1, RIPK3, RIPK4 | RIPK1 1/4885SLC6A4 3049/4885SLC6A2 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.