Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5468578 | 0.83 | ATR (0.38) | ATRCXCR2BACE1ALOX15SRC | |
| SCHEMBL2244599 | 0.77 | ATR (0.40) | ATRCXCR2BACE1ALOX15SRC | |
| SCHEMBL8171638 | 0.77 | BACE1 (0.38) | ATRCXCR2BACE1ALOX15SRC | |
| SCHEMBL5468582 | 0.77 | ATR (0.38) | ATRCXCR2BACE1ALOX15SRC | |
| SCHEMBL10077617 | 0.73 | ATR (0.38) | ATRCXCR2BACE1ALOX15SRC | |
| SCHEMBL8180959 | 0.73 | ALOX15 (0.36) | ATRCXCR2BACE1ALOX15SRC | |
| SCHEMBL6114075 | 0.71 | ATR (0.44) | ATRCXCR2BACE1ALOX15 | |
| SCHEMBL29263826 | 0.71 | ATR (0.39) | ATRCXCR2BACE1ALOX15 | |
| SCHEMBL1441735 | 0.71 | ATR (0.49) | ATRCXCR2BACE1ALOX15 | |
| SCHEMBL5325701 | 0.71 | MPO (0.33) | ATRMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130310433-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2013-11-21 | — | — | US | disclosed |
| US-8481578-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2019826-B1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20120165378-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
| US-8039661-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-18 | — | — | US | disclosed |
| US-20110190507-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-04 | — | — | US | disclosed |
| US-7851495-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-14 | — | — | US | disclosed |
| US-20080070965-A1 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310433-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, PACSIN2 | ATR 628/4885CXCR2 2356/4885BACE1 3413/4885 |
| US-20080070965-A1 | Thiophene-carboxamides useful as inhibitors of protein kinases | MAP3K20, MAP3K5, PACSIN2 | ATR 628/4885CXCR2 2356/4885BACE1 3413/4885 |
| US-20110190507-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, PACSIN2 | ATR 628/4885CXCR2 2356/4885BACE1 3413/4885 |
| US-20120165378-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, PACSIN2 | ATR 628/4885CXCR2 2356/4885BACE1 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.