Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300805 | 0.77 | KDM4E (0.34) | KDM4E | |
| SCHEMBL5910693 | 0.76 | HRH3 (0.57) | SMN1; SMN2LMNASCN5AHRH3CARM1 | |
| SCHEMBL2297928 | 0.76 | DPP4 (0.31) | KDM4E | |
| SCHEMBL5911217 | 0.74 | HRH3 (0.62) | SMN1; SMN2LMNASCN5AHRH3CARM1 | |
| SCHEMBL17526233 | 0.74 | HRH3 (0.55) | SMN1; SMN2LMNASCN5AHRH3CARM1 | |
| SCHEMBL17526224 | 0.74 | HRH3 (0.55) | SMN1; SMN2LMNASCN5AHRH3CARM1 | |
| SCHEMBL2299229 | 0.72 | KDM4E (0.31) | KDM4E | |
| SCHEMBL4381194 | 0.72 | HRH3 (0.59) | SMN1; SMN2LMNASCN5AHRH3CARM1 | |
| SCHEMBL2299127 | 0.71 | — | — | |
| SCHEMBL2297692 | 0.71 | TDP1 (0.41) | SMN1; SMN2LMNAHRH3CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |