Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295412 | 0.95 | PAOX (0.38) | TDP1KMT2ASMN1; SMN2PAOXDPP7 | |
| SCHEMBL2295851 | 0.89 | CYP2C9 (0.38) | KMT2ASMN1; SMN2ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL2300805 | 0.81 | KDM4E (0.34) | KDM4E | |
| SCHEMBL2297928 | 0.79 | DPP4 (0.31) | KDM4E | |
| SCHEMBL2299229 | 0.77 | KDM4E (0.31) | KDM4E | |
| SCHEMBL2299127 | 0.75 | — | — | |
| SCHEMBL2300241 | 0.72 | KDM4E (0.41) | TDP1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2294529 | 0.72 | GLB1 (0.33) | SMN1; SMN2ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL2296596 | 0.71 | SMN1; SMN2 (0.40) | KMT2ASMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL2296528 | 0.70 | SIGMAR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | claimed |