Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PER2 | O15055 | 4/20 | 0.46 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.46 |
| ▸ | CRY1 | Q16526 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNJ4 | P48050 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22967285 | 0.91 | ALOX15 (0.77) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22967292 | 0.83 | ALOX15 (0.47) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL29930181 | 0.83 | KDM4E (0.89) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL9769990 | 0.73 | ALDH1A1 (0.65) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22967278 | 0.73 | MAPT (0.53) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22967304 | 0.73 | CNR2 (0.48) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| Hydrochloric Acid SCHEMBL9690565 | 0.72 | ALDH1A1 (0.65) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22640019 | 0.69 | KDM4E (0.79) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL29930278 | 0.68 | ALOX15 (0.66) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL16211042 | 0.68 | RAD52 (0.76) | ALOX15HSD17B10MAPTTHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026185-A1 | INDOLE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2021-02-11 | — | — | WO | disclosed |