Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CRY2 | Q49AN0 | 8/20 | 0.54 |
| ▸ | PER2 | O15055 | 6/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CRY1 | Q16526 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22967286 | 0.91 | ALOX15 (0.67) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL29930181 | 0.83 | KDM4E (0.89) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22967278 | 0.82 | MAPT (0.53) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL9769990 | 0.80 | ALDH1A1 (0.65) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| Hydrochloric Acid SCHEMBL9690565 | 0.78 | ALDH1A1 (0.65) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22967304 | 0.77 | CNR2 (0.48) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL22967292 | 0.74 | ALOX15 (0.47) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL16211042 | 0.73 | RAD52 (0.76) | ALOX15HSD17B10MAPTTHRBKDM4E | |
| SCHEMBL16210953 | 0.73 | BAX (0.72) | ALOX15HSD17B10MAPTTHRBALDH1A1 | |
| SCHEMBL15383995 | 0.72 | PER2 (0.64) | CRY2PER2CRY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220296604-A1 | INDOLE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2022-09-22 | — | — | US | disclosed |
| WO-2021026185-A1 | INDOLE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2021-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220296604-A1 | INDOLE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, HMGB1, GPR119 | ALOX15 525/4885HSD17B10 3540/4885MAPT 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.