Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
| ▸ | GABRE | P78334 | 1/20 | 0.30 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.30 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.30 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935205 | 0.70 | EPHX2 (0.33) | EPHX2GABRB3ALDH1A1TSHRGABRP | |
| SCHEMBL29749490 | 0.70 | EPHX2 (0.33) | EPHX2GABRB3ALDH1A1TSHRGABRP | |
| SCHEMBL1258424 | 0.70 | EPHX2 (0.33) | EPHX2NOS3NOS2GABRB3ALDH1A1 | |
| SCHEMBL22968355 | 0.69 | — | — | |
| SCHEMBL31010274 | 0.67 | AR (0.32) | EPHX2ALDH1A1GABRA2GABRB2 | |
| SCHEMBL22056126 | 0.65 | KDM4E (0.33) | EPHX2ALDH1A1 | |
| SCHEMBL15723839 | 0.65 | ACHE (0.53) | — | |
| SCHEMBL16798341 | 0.65 | KCNH2 (0.35) | EPHX2 | |
| SCHEMBL22492989 | 0.65 | NOS1 (0.35) | EPHX2 | |
| SCHEMBL2188206 | 0.65 | KCNH2 (0.35) | EPHX2GABRB3ALDH1A1GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11583532-B2 | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-02-21 | — | — | US | disclosed |
| US-20210038603-A1 | TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2021-02-11 | — | — | US | disclosed |
| CN-104114555-B | Pyrazolopyrimidine derivatives, process for their preparation and their therapeutic use | 赛诺菲 | 2017-09-01 | — | — | CN | disclosed |
| CN-106317056-A | Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof | 赛诺菲 | 2017-01-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038603-A1 | TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | MBOAT4, GIPR, MTTP | EPHX2 3661/4885NOS3 2024/4885NOS2 2484/4885 |
| US-11583532-B2 | Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors | MBOAT4, GIPR, MTTP | EPHX2 3661/4885NOS3 2024/4885NOS2 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.