Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16707142 | 0.82 | BRD4 (0.40) | HCAR3BRD4 | |
| SCHEMBL19672501 | 0.82 | BRD4 (0.40) | HCAR3BRD4 | |
| SCHEMBL17254668 | 0.79 | CRHBP (0.55) | SMN1; SMN2LMNARECQLALDH1A1MAPT | |
| SCHEMBL17254671 | 0.74 | ESPL1 (0.40) | SMN1; SMN2LMNACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL2488278 | 0.72 | TDP1 (0.56) | LMNACYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL5559030 | 0.72 | TDP1 (0.39) | SMN1; SMN2LMNACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL2488921 | 0.70 | LMNA (0.51) | SMN1; SMN2LMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL19672457 | 0.70 | BRD4 (0.39) | HCAR3BRD4MAPTPOLBMEN1 | |
| SCHEMBL16703654 | 0.70 | BRD4 (0.39) | HCAR3BRD4MAPTPOLBMEN1 | |
| SCHEMBL5561741 | 0.68 | MAPT (0.43) | SMN1; SMN2LMNAALDH1A1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210038602-A1 | COMBINATION TREATMENT OF ACUTE MYELOID LEUKEMIA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038602-A1 | COMBINATION TREATMENT OF ACUTE MYELOID LEUKEMIA | BRD4, MCL1, BET1 | HCAR3 1489/4885SMN1; SMN2 4148/4885BRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.