Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29620947 | 0.85 | CSF1R (0.49) | NPC1RAB9AMAOBCSF1RNTRK1 | |
| SCHEMBL22925707 | 0.85 | CSF1R (0.49) | NPC1RAB9AMAOBCSF1RNTRK1 | |
| SCHEMBL27107675 | 0.83 | NPC1 (0.46) | NPC1RAB9AMAOBCSF1RNTRK1 | |
| SCHEMBL31723905 | 0.82 | MAPK14 (0.47) | NPC1RAB9AMAOBALDH1A1POLB | |
| SCHEMBL190649 | 0.79 | MAOB (0.51) | NPC1RAB9AMAOBALDH1A1APP | |
| SCHEMBL20382912 | 0.77 | NPC1 (0.46) | NPC1RAB9AMAOBCSF1RNTRK1 | |
| SCHEMBL28988132 | 0.77 | NPC1 (0.49) | NPC1RAB9AMAOBCSF1RNTRK1 | |
| SCHEMBL30388779 | 0.77 | NPC1 (0.49) | NPC1RAB9AMAOBCSF1RNTRK1 | |
| SCHEMBL22925872 | 0.77 | MAOB (0.50) | NPC1RAB9AMAOBCSF1RAPP | |
| SCHEMBL29620984 | 0.77 | MAOB (0.50) | NPC1RAB9AMAOBCSF1RAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010314-B1 | HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-4010314-B1 | HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2021026047-A1 | HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2021-02-11 | — | — | WO | disclosed |